Human Anti-FGFR3 Recombinant Antibody (clone R3Mab) (CAT#: PABL-474)
Recombinant Human Antibody (R3Mab) is capable of binding to FGFR3, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-FGFR3 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-FGFR3 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody inhibited not only WT FGFR3, but also various mutants of the receptor.
Specific Inquiry
Figure 1 Blocking of R3Mab to FGF-FGFR3 interaction.
(A) Selective binding of human FGFR3 by R3Mab. Human FGFR1–4 Fc chimeric proteins were immobilized and incubated with increasing amounts of R3Mab. Specific binding was detected using an anti-human Fab antibody. (B and C) Blocking of FGF1 binding to human FGFR3-IIIb (B) or -IIIc (C) by R3Mab. Specific binding was detected by using a biotinylated FGF1-specific polyclonal antibody. (D and E) Blocking of FGF9 binding to human FGFR3-IIIb (D) or -IIIc (E) by R3Mab. Specific binding was detected by using a biotinylated FGF9-specific polyclonal antibody. Error bars represent SEM and are sometimes smaller than symbols.
Qing, J., Du, X., Chen, Y., Chan, P., Li, H., Wu, P., ... & Ross, S. (2009). Antibody-based targeting of FGFR3 in bladder carcinoma and t (4; 14)-positive multiple myeloma in mice. The Journal of clinical investigation, 119(5), 1216-1229.
Specifications
- Immunogen
- Human fibroblast growth factor receptor 3
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human FGFR3
- Species Reactivity
- Human
- Clone
- R3Mab
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; fibroblast growth factor receptor 3 variant 4
- Gene ID
- 2261
- UniProt ID
- P22607
Related Resources
Bladder Cancer
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G028E | Anti-FGFR3 immunotoxin (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G028G | Anti-FGFR3 immunotoxin (scFv)-Gel | Cytotoxicity assay, Function study | |
| AGTO-L016E | aFGF-PE immunotoxin | Cytotoxicity assay, Functional assay | |
| AGTO-L016G | aFGF-Gel immunotoxin | Cytotoxicity assay, Functional assay |
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# PABL-474, RRID: AB_3111659)
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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